Regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A4, COX19, and INSIG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC30A4 grouped by Regulation of cell-substrate adhesion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC30A4 →	+0.483	+0.252	.002	.009	3	5
BLOOD_Myeloma	COX19 →	+0.987	+1.058	.004	.007	3	4
OVARY	INSIG1 →	-1.139	-0.461	.004	.008	3	3
BREAST	ATP5PO →	+0.661	+0.133	<.001	.005	2	4
LUNG_NSCLC_LUAD	RARB →	+1.370	+0.333	.008	.009	3	3
LIVER	SIRT2 →	+1.283	+0.336	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC30A4 by Regulation of cell-substrate adhesion activity — BREAST

Explore this box plot interactively →