Negative regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB1I1, VCL_S795, and LMO7_S194, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tumor necrosis factor-mediated signaling pathway activity versus TGFB1I1 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TGFB1I1 →	+0.382	+0.028	.002	.001	3	5
BRCA	VCL_S795 →	+0.432	+0.032	.001	<.001	3	5
CCRCC	LMO7_S194 →	+0.341	+0.035	.001	.003	3	5
LSCC	COPB2 →	-0.177	-0.039	.003	<.001	3	4
LSCC	MON1B →	-0.157	-0.041	.001	.002	3	4
UCEC	MYH11_S638 →	+0.858	+0.058	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010804 vs TGFB1I1 — BRCA

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