Negative regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF14, TMEM177, and MUC20, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tumor necrosis factor-mediated signaling pathway activity versus TNFRSF14 in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TNFRSF14 →	+2.144	+0.077	<.001	<.001	3	7
SKIN	TMEM177 →	-0.849	-0.073	<.001	<.001	3	7
PANCREAS	MUC20 →	+2.037	+0.057	.001	.001	3	7
BLOOD_Lymphoma	GBP3 →	+1.499	+0.110	<.001	<.001	3	7
OVARY	H2BC5 →	+1.380	+0.088	.002	.001	3	7
BLOOD_Lymphoma	H2AC11 →	+0.822	+0.099	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010804 vs TNFRSF14 — STOMACH

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