Negative regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTP1, CIB1, and EEPD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tumor necrosis factor-mediated signaling pathway activity versus GSTP1 in BLOOD_Myeloma (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GSTP1 →	+6.391	+1.891	<.001	<.001	3	8
LUNG_SCLC	CIB1 →	+1.237	+1.651	<.001	<.001	3	7
BLOOD_Lymphoma	EEPD1 →	+2.157	+0.587	<.001	.001	3	6
OVARY	ANXA4 →	+4.217	+0.639	<.001	<.001	3	6
OVARY	TRNP1 →	+2.138	+0.465	.002	<.001	3	5
LARGE_INTESTINE	FRMD6 →	-2.751	-0.673	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010804 vs GSTP1 — BLOOD_Myeloma

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