Negative regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSTP1, ANXA4, and CFL1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tumor necrosis factor-mediated signaling pathway activity versus GSTP1 in BLOOD_Myeloma (Pearson r = 0.88).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GSTP1 →	+6.405	+1.907	.005	<.001	3	19
OVARY	ANXA4 →	+3.203	+0.701	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	CFL1 →	+1.757	+0.644	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	TALDO1 →	+2.002	+0.884	<.001	<.001	3	9
SKIN	CHMP4B →	+0.876	+0.412	<.001	.005	3	8
UPPER_AERODIGESTIVE_TRACT	IDH1 →	+2.876	+0.881	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010804 vs GSTP1 — BLOOD_Myeloma

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