Regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALLD, VCL_S795, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tumor necrosis factor-mediated signaling pathway activity versus PALLD in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PALLD →	+0.528	+0.028	.003	.002	3	7
BRCA	VCL_S795 →	+0.546	+0.034	<.001	<.001	3	7
OV	RPL5 →	-0.178	-0.041	<.001	.002	3	6
OV	VCL_S726 →	+0.911	+0.056	.004	.001	3	6
CCRCC	PDLIM7 →	+0.542	+0.025	.002	.007	3	6
OV	TUBB6 →	+0.407	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010803 vs PALLD — CCRCC

Explore this scatter interactively →