Regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WIPF1, ARMCX5, and ADGRE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tumor necrosis factor-mediated signaling pathway activity versus WIPF1 in LSCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WIPF1 →	+0.455	+0.139	.004	.002	3	5
GBM	ARMCX5 →	-0.433	-0.222	<.001	<.001	3	5
GBM	ADGRE2 →	+0.743	+0.218	<.001	<.001	3	5
GBM	SAMSN1 →	+0.915	+0.186	<.001	<.001	3	5
GBM	FCER1G →	+0.909	+0.214	<.001	<.001	3	5
GBM	CCR1 →	+0.922	+0.197	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010803 vs WIPF1 — LSCC

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