Regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTHFR, GNG10, and KIF22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTHFR grouped by Regulation of tumor necrosis factor-mediated signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MTHFR →	+1.155	+1.267	<.001	<.001	3	5
SKIN	GNG10 →	-0.662	-1.204	<.001	<.001	3	5
BREAST	KIF22 →	+0.665	+0.643	<.001	.001	3	5
PANCREAS	BCAR1 →	+0.994	+0.941	.009	.007	3	4
BONE	FCGRT →	+3.910	+1.260	<.001	.001	3	4
BONE	MAZ →	+0.889	+1.442	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTHFR by Regulation of tumor necrosis factor-mediated signaling pathway activity — BONE

Explore this box plot interactively →