Regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC11, TEX29, and PDE3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tumor necrosis factor-mediated signaling pathway activity versus H2BC11 in BONE (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	H2BC11 →	-2.969	-1.490	.001	.001	3	5
SKIN	TEX29 →	-0.145	-0.368	.004	.009	3	5
LUNG_SCLC	PDE3B →	+1.229	+0.737	.001	.009	3	5
BONE	ADTRP →	-1.228	-1.430	<.001	.001	3	4
BONE	H1-2 →	-3.353	-1.379	.005	.001	3	4
URINARY_TRACT	PLEKHH2 →	+1.866	+1.520	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010803 vs H2BC11 — BONE

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