Negative regulation of peptidyl-threonine phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G, IGFBP7, and LARP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-threonine phosphorylation activity versus EIF3G in COAD (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF3G →	-0.171	-0.037	<.001	.001	3	7
LSCC	IGFBP7 →	+0.341	+0.053	.009	.001	3	7
BRCA	LARP1 →	-0.257	-0.057	<.001	<.001	3	7
CCRCC	PRKG1 →	+0.452	+0.048	<.001	<.001	3	7
LSCC	CSRP1 →	+0.387	+0.055	.006	.004	3	7
CCRCC	SVIL_S467 →	+0.809	+0.055	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010801 vs EIF3G — COAD

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