Positive regulation of peptidyl-threonine phosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLH, YY2, and PHF12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLH grouped by Positive regulation of peptidyl-threonine phosphorylation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	POLH →	-1.029	-1.273	.003	.002	3	4
SOFT_TISSUE	YY2 →	-0.856	-1.619	.007	<.001	3	4
PANCREAS	PHF12 →	-0.601	-1.282	.003	.001	3	3
PANCREAS	LAMP2 →	+0.788	+1.274	.002	<.001	3	3
BLOOD_Myeloma	KAT2A →	-0.943	-1.279	.003	.004	2	4
BLOOD_Myeloma	WDFY3 →	-2.523	-1.316	.002	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLH by Positive regulation of peptidyl-threonine phosphorylation activity — LUNG_SCLC

Explore this box plot interactively →