Positive regulation of peptidyl-threonine phosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK1, HIRA, and WIZ, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidyl-threonine phosphorylation activity versus MAPK1 in LIVER (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MAPK1 →	+1.472	+0.294	.009	.004	2	16
PANCREAS	HIRA →	+0.924	+0.220	.003	.001	3	11
LIVER	WIZ →	+0.964	+0.334	.001	<.001	3	10
LIVER	SNAP29 →	+1.335	+0.339	.005	<.001	3	10
BLOOD_Myeloma	UBE2L3 →	+1.056	+0.242	.006	.007	2	11
PANCREAS	SPECC1L →	+0.675	+0.181	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010800 vs MAPK1 — LIVER

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