Positive regulation of peptidyl-threonine phosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDA, PUS10, and PLCL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidyl-threonine phosphorylation activity versus CDA in LARGE_INTESTINE (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDA →	-2.966	-1.689	<.001	.001	3	3
LARGE_INTESTINE	PUS10 →	-0.357	-1.093	.003	.002	3	3
LUNG_SCLC	PLCL2 →	+1.605	+0.325	.008	.001	3	3
LUNG_SCLC	SEMA4D →	+1.688	+0.356	<.001	<.001	3	3
LUNG_SCLC	MAP3K9 →	+0.976	+0.294	.004	.006	3	3
LUNG_SCLC	PIAS2 →	+1.048	+0.294	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010800 vs CDA — LARGE_INTESTINE

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