Regulation of peptidyl-threonine phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMBIM1, S100A10, and TNKS1BP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-threonine phosphorylation activity versus TMBIM1 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMBIM1 →	+0.957	+0.287	.002	<.001	3	6
BRCA	S100A10 →	+0.569	+0.321	.008	.001	3	5
HNSC	TNKS1BP1 →	+0.754	+0.256	<.001	<.001	3	5
HNSC	ACVR2B →	-0.536	-0.206	.002	.005	3	5
LSCC	ZNF891 →	-0.439	-0.201	<.001	<.001	3	5
LUAD	MEX3A →	-0.842	-0.161	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010799 vs TMBIM1 — HNSC

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