Negative regulation of sodium ion transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of sodium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HECW2_S1042, NEDD4L, and DNM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sodium ion transport activity versus HECW2_S1042 in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HECW2_S1042 →	+0.942	+0.067	<.001	<.001	3	5
BRCA	NEDD4L →	+0.416	+0.049	.001	.001	3	5
OV	DNM1 →	+0.519	+0.054	<.001	<.001	3	5
LSCC	PCSK9 →	+0.822	+0.073	<.001	<.001	3	4
LSCC	PNISR_S304 →	-0.399	-0.045	.003	.007	3	4
GBM	SP110_S244 →	-0.437	-0.055	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010766 vs HECW2_S1042 — LUAD

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