Negative regulation of sodium ion transport

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of sodium ion transport pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Negative regulation of sodium ion transport pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and UVM, show the opposite pattern, with higher activity associated with better survival.

KIRC, UVM, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.916	0.833	<.001	120	view →
UVM	OS	Median	All	0.799	0.383	<.001	75	view →
BRCA	OS	Tertile	II,III,IV	0.962	0.883	<.001	69	view →
STAD	OS	Tertile	II,III,IV	0.301	0.641	<.001	43	view →
UCEC	OS	Median	III,IV	0.774	0.872	.004	32	view →
SKCM	DFS	Tertile	All	0.240	0.146	.003	30	view →
BLCA	DFS	Tertile	IV	0.087	0.235	.007	28	view →
KIRP	DFS	Tertile	III,IV	0.220	0.801	.003	18	view →
COAD	DFS	Quartile	IV	0.592	0.252	.011	18	view →
LAML	DFS	Median	All	0.493	0.638	.029	16	view →
PAAD	OS	Quartile	All	0.778	0.511	.009	16	view →
CHOL	DFS	Quartile	II,III,IV	0.133	0.508	.046	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0010766–KIRC (OS)

Open the KIRC breakdown →