Negative regulation of sodium ion transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F1, HECW2, and SLC51B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sodium ion transport activity versus E2F1 in LSCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	E2F1 →	-0.591	-0.345	.004	.007	3	4
LSCC	HECW2 →	+0.459	+0.538	<.001	.001	3	4
LSCC	SLC51B →	+0.343	+0.327	.002	.003	3	4
LUAD	CDCA2 →	-0.565	-0.202	.005	.007	3	4
LUAD	CDC45 →	-0.656	-0.265	.003	.009	3	4
GBM	ASF1B →	-0.605	-0.564	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010766 vs E2F1 — LSCC

Explore this scatter interactively →