Negative regulation of sodium ion transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELMO3, BIRC2, and ZRANB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELMO3 grouped by Negative regulation of sodium ion transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ELMO3 →	+1.694	+1.132	.005	.001	3	5
BREAST	BIRC2 →	-0.933	-0.841	.001	.002	3	4
LUNG_NSCLC_LUAD	ZRANB2 →	-0.817	-1.003	<.001	.001	3	4
BONE	EXOSC10 →	-0.877	-1.980	.004	<.001	3	4
BREAST	C9orf152 →	+1.600	+0.665	.001	.004	3	4
LUNG_NSCLC_LUAD	IL1RAP →	-1.069	-0.877	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELMO3 by Negative regulation of sodium ion transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →