Positive regulation of sodium ion transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPSTI1, PCCB, and PASK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sodium ion transport activity versus EPSTI1 in CNS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EPSTI1 →	+3.256	+0.324	.001	.003	3	7
UPPER_AERODIGESTIVE_TRACT	PCCB →	-1.168	-0.449	.008	.003	3	6
LARGE_INTESTINE	PASK →	-0.501	-0.191	.003	.008	3	6
URINARY_TRACT	METTL21A →	-1.082	-0.500	.001	.005	3	5
LUNG_SCLC	SPATS2L →	+2.010	+0.221	.007	.008	3	5
SOFT_TISSUE	GPR39 →	+2.057	+0.305	.004	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010765 vs EPSTI1 — CNS

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