Fibroblast migration

Across TCGA patient cohorts, RNA activity of the Fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, SEPTIN4, and ATP1A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast migration activity versus MYL9 in COAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYL9 →	+1.338	+1.276	<.001	<.001	3	5
CCRCC	SEPTIN4 →	+0.501	+0.248	.001	.004	3	5
BRCA	ATP1A2 →	+0.804	+0.443	<.001	<.001	3	5
BRCA	LINC00702 →	+0.563	+0.493	<.001	<.001	3	5
CCRCC	LHFPL6 →	+0.864	+0.318	<.001	<.001	3	5
CCRCC	TIMP3 →	+1.426	+0.406	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010761 vs MYL9 — COAD

Explore this scatter interactively →