Negative regulation of plasminogen activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of plasminogen activation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRPX2, ACTN1, and COL5A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of plasminogen activation activity versus SRPX2 in COAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SRPX2 →	+0.913	+0.107	<.001	<.001	3	10
OV	ACTN1 →	+0.492	+0.081	<.001	<.001	3	10
BRCA	COL5A1 →	+0.611	+0.061	<.001	<.001	3	10
LSCC	FKBP10 →	+0.459	+0.084	<.001	<.001	3	10
OV	FN1 →	+1.172	+0.108	<.001	<.001	3	10
OV	MRC2 →	+0.691	+0.122	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010757 vs SRPX2 — COAD

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