Negative regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of plasminogen activation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSX2, FPR2, and TRIO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VSX2 grouped by Negative regulation of plasminogen activation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	VSX2 →	-0.540	-1.638	.006	.003	3	6
BREAST	FPR2 →	-0.202	-0.368	<.001	.002	3	6
LUNG_NSCLC_LUAD	TRIO →	+0.140	+0.214	<.001	.002	3	5
LUNG_NSCLC_LUSC	ZNF343 →	+0.205	+0.337	.004	.002	3	5
LARGE_INTESTINE	FAM167A →	+0.389	+0.294	.001	.002	3	5
BREAST	ACLY →	-0.255	-0.390	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSX2 by Negative regulation of plasminogen activation activity — BONE

Explore this box plot interactively →