Negative regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of plasminogen activation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP2, ZNF557, and GYPC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBP2 grouped by Negative regulation of plasminogen activation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RBP2 →	-0.131	-1.048	.005	.002	3	3
LARGE_INTESTINE	ZNF557 →	-0.190	-0.296	<.001	.005	3	3
BREAST	GYPC →	-0.191	-0.453	<.001	<.001	3	3
SKIN	MLXIP →	-0.160	-0.362	.005	.001	2	3
SKIN	ALDH1A3 →	-0.178	-0.317	.002	.003	2	3
SKIN	PDE6G →	-0.241	-0.355	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBP2 by Negative regulation of plasminogen activation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →