Negative regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of plasminogen activation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YKT6, ARF4, and TFAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of plasminogen activation activity versus YKT6 in SKIN (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	YKT6 →	+1.067	+0.343	.008	<.001	3	5
SKIN	ARF4 →	+0.708	+0.312	<.001	<.001	3	4
SOFT_TISSUE	TFAP4 →	-1.545	-1.636	.009	.001	1	5
LARGE_INTESTINE	NELFA →	-0.519	-0.668	.006	.004	3	3
KIDNEY	MYBBP1A →	-0.879	-0.410	.007	<.001	3	3
KIDNEY	TACC2 →	-1.466	-0.461	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010757 vs YKT6 — SKIN

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