Positive regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of plasminogen activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC3, NAIF1, and ZNF546, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMC3 grouped by Positive regulation of plasminogen activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EMC3 →	-0.894	-1.629	.001	.001	3	5
BLOOD_Leukemia	NAIF1 →	-0.538	-1.471	.001	<.001	3	5
URINARY_TRACT	ZNF546 →	-0.845	-1.662	.001	<.001	3	5
STOMACH	CPEB4 →	-1.376	-1.258	<.001	.002	3	4
PANCREAS	UBXN6 →	-0.514	-1.138	.001	<.001	3	4
BLOOD_Myeloma	MESD →	+0.936	+1.603	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMC3 by Positive regulation of plasminogen activation activity — STOMACH

Explore this box plot interactively →