Negative regulation of cGMP-mediated signaling

Across TCGA patient cohorts, RNA activity of the Negative regulation of cGMP-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA5, PLAU, and FOSL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cGMP-mediated signaling activity versus ITGA5 in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ITGA5 →	+0.441	+0.050	.001	<.001	3	5
PDAC	PLAU →	+0.608	+0.053	<.001	.002	3	5
OV	FOSL2 →	+0.326	+0.082	.002	.001	3	5
OV	CD44 →	+0.388	+0.113	.002	.003	2	5
HNSC	ERG_S81 →	-0.293	-0.059	<.001	.005	3	4
HNSC	HAGH →	-0.334	-0.080	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010754 vs ITGA5 — PDAC

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