Negative regulation of cGMP-mediated signaling

Across TCGA patient cohorts, RNA activity of the Negative regulation of cGMP-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDXP, SNX2P1, and LMAN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cGMP-mediated signaling activity versus PDXP in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PDXP →	+0.394	+0.131	.001	<.001	3	4
PDAC	SNX2P1 →	-0.332	-1.129	<.001	.001	3	3
PDAC	LMAN1 →	-0.391	-0.987	<.001	.002	3	3
CCRCC	HMGB1P23 →	-0.406	-0.834	.006	.002	3	3
LUAD	PLEKHA2 →	-0.501	-0.792	.006	.003	3	3
GBM	STMN2 →	+2.199	+0.165	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010754 vs PDXP — GBM

Explore this scatter interactively →