Negative regulation of cGMP-mediated signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of cGMP-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, BMP1, and CCDC80, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cGMP-mediated signaling activity versus THBS1 in BONE (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	THBS1 →	+5.860	+1.795	<.001	<.001	3	18
BONE	BMP1 →	+1.976	+2.103	<.001	<.001	3	11
STOMACH	CCDC80 →	+4.751	+1.787	<.001	<.001	3	10
BONE	LTBP2 →	+2.831	+1.742	<.001	<.001	3	10
LUNG_NSCLC_LUSC	EDN1 →	+2.702	+1.020	<.001	<.001	3	9
BONE	EFEMP1 →	+4.398	+1.465	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010754 vs THBS1 — BONE

Explore this scatter interactively →