Regulation of hydrogen peroxide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of hydrogen peroxide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF4, TRAV8-2, and PILRA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide biosynthetic process activity versus NCF4 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCF4 →	+0.862	+0.625	.001	.005	2	6
BRCA	TRAV8-2 →	+0.926	+0.562	<.001	.001	3	4
BRCA	PILRA →	+0.943	+0.776	<.001	<.001	3	4
LUAD	CYTH4 →	+0.542	+0.742	<.001	<.001	3	4
LUAD	NCF2 →	+0.493	+0.502	<.001	.003	3	4
GBM	ST8SIA1 →	+0.730	+0.217	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010728 vs NCF4 — BRCA

Explore this scatter interactively →