Regulation of hydrogen peroxide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of hydrogen peroxide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RESF1, CCDC14, and BAZ1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RESF1 grouped by Regulation of hydrogen peroxide biosynthetic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RESF1 →	-0.503	-0.606	.001	.003	3	3
CNS	CCDC14 →	-0.729	-0.654	<.001	.001	3	3
PANCREAS	BAZ1A →	+0.842	+0.821	.009	.009	3	3
PANCREAS	KIF27 →	-0.744	-0.803	<.001	.006	3	3
BLOOD_Leukemia	HACE1 →	-1.200	-0.267	.001	.005	3	3
OVARY	DPP3 →	+0.482	+0.282	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RESF1 by Regulation of hydrogen peroxide biosynthetic process activity — CNS

Explore this box plot interactively →