Regulation of hydrogen peroxide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of hydrogen peroxide biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WIPI2, PHLPP2, and GPR101, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WIPI2 grouped by Regulation of hydrogen peroxide biosynthetic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	WIPI2 →	-0.173	-0.093	.003	.002	3	5
BREAST	PHLPP2 →	+0.128	+0.095	.001	.004	3	4
SOFT_TISSUE	GPR101 →	+0.177	+0.165	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PPP1R14A →	-0.203	-0.173	.001	<.001	3	4
BONE	SDR16C5 →	-0.345	-0.399	<.001	.007	3	4
LUNG_SCLC	H1-9P →	+0.218	+0.248	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WIPI2 by Regulation of hydrogen peroxide biosynthetic process activity — OESOPHAGUS

Explore this box plot interactively →