Positive regulation of hydrogen peroxide metabolic process

pathway activity — cross-omics
GO:0010726Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of hydrogen peroxide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TUBB6, GPX7, and NNT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACTUBB6 →-0.532-0.087<.001<.00136
OVGPX7 →-0.610-0.071<.001<.00136
BRCANNT →+0.493+0.080.001<.00135
OVITGA5 →-0.530-0.078<.001<.00135
OVF13A1 →-0.725-0.074<.001<.00135
BRCAGSN →-0.729-0.075<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration