Negative regulation of epithelial to mesenchymal transition

Across TCGA patient cohorts, RNA activity of the Negative regulation of epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBN1, SPARC, and TLL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial to mesenchymal transition activity versus FBN1 in LUAD (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FBN1 →	+0.673	+0.185	.004	.002	3	7
UCEC	SPARC →	+0.688	+0.262	.007	.004	3	7
LSCC	TLL1 →	+0.519	+0.187	.004	.007	3	7
BRCA	RGS4 →	+1.154	+0.558	<.001	.002	3	6
OV	PABPC4L →	+0.627	+0.359	.001	.001	3	6
HNSC	SCARF2 →	+0.454	+0.189	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010719 vs FBN1 — LUAD

Explore this scatter interactively →