Negative regulation of epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial to mesenchymal transition pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2CA, FOXA2, and TCF3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP2CA grouped by Negative regulation of epithelial to mesenchymal transition-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PPP2CA →	-0.381	-0.830	.004	.009	3	7
BLOOD_Leukemia	FOXA2 →	-0.209	-1.030	.002	<.001	3	6
KIDNEY	TCF3 →	-0.266	-1.483	<.001	<.001	3	5
BONE	SMAD7 →	-0.178	-0.973	.001	.006	3	5
LIVER	TAB2 →	-0.223	-1.428	.005	.002	3	5
OVARY	CAMKK1 →	-0.228	-0.734	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP2CA by Negative regulation of epithelial to mesenchymal transition activity — SOFT_TISSUE

Explore this box plot interactively →