Negative regulation of epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIG1, SCHIP1, and ALDH16A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIG1 grouped by Negative regulation of epithelial to mesenchymal transition-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LIG1 →	+0.698	+0.380	.002	.008	3	5
SOFT_TISSUE	SCHIP1 →	-3.201	-1.220	.001	.001	3	5
BREAST	ALDH16A1 →	+0.710	+0.405	<.001	.004	3	5
BREAST	EPN3 →	+2.502	+0.471	<.001	<.001	3	4
BREAST	MRC2 →	-2.571	-0.517	<.001	.001	3	4
BREAST	KLF12 →	-0.852	-0.572	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIG1 by Negative regulation of epithelial to mesenchymal transition activity — BREAST

Explore this box plot interactively →