Negative regulation of epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSG2, DHX57, and TC2N, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial to mesenchymal transition activity versus DSG2 in OESOPHAGUS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DSG2 →	+2.044	+1.300	.002	<.001	3	6
SKIN	DHX57 →	-0.603	-1.306	.002	.004	3	5
OESOPHAGUS	TC2N →	+1.614	+1.048	.005	.006	2	5
SKIN	ANKRD34A →	-0.927	-1.419	<.001	<.001	3	4
CNS	CYB5D1 →	-0.733	-1.017	.009	.008	3	4
LUNG_NSCLC_LUAD	FA2H →	+1.739	+1.076	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010719 vs DSG2 — OESOPHAGUS

Explore this scatter interactively →