Positive regulation of epithelial to mesenchymal transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial to mesenchymal transition pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C8B, CCDC80, and CRTAP, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial to mesenchymal transition activity versus C8B in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C8B →	+0.646	+0.042	<.001	.001	3	10
BRCA	CCDC80 →	+0.825	+0.057	<.001	<.001	3	10
LSCC	CRTAP →	+0.620	+0.081	<.001	<.001	3	10
CCRCC	CTHRC1 →	+0.905	+0.050	<.001	<.001	3	10
GBM	EMILIN1 →	+0.659	+0.065	<.001	<.001	3	10
OV	LGALS1_S30 →	+1.103	+0.062	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010718 vs C8B — GBM

Explore this scatter interactively →