Regulation of epithelial to mesenchymal transition

Across TCGA patient cohorts, RNA activity of the Regulation of epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBN1, IGFBP7, and LINC00702, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial to mesenchymal transition activity versus FBN1 in OV (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FBN1 →	+1.220	+0.919	.002	.001	3	8
OV	IGFBP7 →	+1.068	+1.082	<.001	<.001	3	7
COAD	LINC00702 →	+0.466	+0.667	<.001	<.001	3	7
OV	MAGI2-AS3 →	+0.846	+0.910	.001	.002	3	7
UCEC	CHSY3 →	+1.094	+1.196	.002	.005	3	7
COAD	NUDT10 →	+0.773	+0.618	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010717 vs FBN1 — OV

Explore this scatter interactively →