Regulation of extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Regulation of extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT8, NFE2L3, and CXCL8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KAT8 grouped by Regulation of extracellular matrix disassembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KAT8 →	+0.784	+0.331	.005	.004	2	5
OESOPHAGUS	NFE2L3 →	+1.746	+0.330	.001	<.001	3	4
STOMACH	CXCL8 →	-3.173	-0.292	.003	<.001	2	4
BONE	AP3M1 →	-0.305	-0.332	.002	.006	3	3
BONE	TUBG2 →	+1.354	+0.386	.009	<.001	3	3
BONE	PKM →	-0.875	-0.484	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KAT8 by Regulation of extracellular matrix disassembly activity — OESOPHAGUS

Explore this box plot interactively →