Regulation of extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Regulation of extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2IP, MRPS12, and ELP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extracellular matrix disassembly activity versus DAB2IP in BLOOD_Lymphoma (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DAB2IP →	+1.680	+1.086	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MRPS12 →	-0.925	-1.424	.001	<.001	3	4
BLOOD_Lymphoma	ELP6 →	-0.740	-1.193	<.001	.001	3	4
LIVER	CD276 →	+1.270	+1.423	.005	.003	3	4
LIVER	PWWP2A →	-0.544	-1.480	.001	<.001	3	4
BLOOD_Lymphoma	LRRC8C →	+1.577	+1.811	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010715 vs DAB2IP — BLOOD_Lymphoma

Explore this scatter interactively →