Positive regulation of striated muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of striated muscle cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSH1_S1042, SIPA1_S74, and BNIP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of striated muscle cell apoptotic process activity versus SSH1_S1042 in PDAC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SSH1_S1042 →	-0.470	-0.049	<.001	.001	3	6
GBM	SIPA1_S74 →	-0.533	-0.072	.003	.003	3	5
CCRCC	BNIP3 →	+0.572	+0.062	<.001	<.001	3	4
LSCC	MAP1A →	+0.296	+0.051	.004	<.001	3	4
LSCC	MAP2 →	+0.672	+0.072	.001	.001	3	4
LSCC	NEDD4L →	+0.549	+0.072	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010663 vs SSH1_S1042 — PDAC

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