Positive regulation of striated muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of striated muscle cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53, ATP2A2, and ADCY10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TP53 grouped by Positive regulation of striated muscle cell apoptotic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TP53 →	-0.892	-1.704	.001	<.001	3	9
KIDNEY	ATP2A2 →	-0.635	-1.640	<.001	.001	3	8
BREAST	ADCY10 →	-0.116	-0.505	.003	.004	3	7
LUNG_NSCLC_LUSC	LINC00869 →	+0.403	+1.403	<.001	<.001	3	6
SOFT_TISSUE	CAMK2A →	-0.510	-1.766	<.001	.004	3	5
OVARY	NUTF2 →	-0.524	-1.549	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TP53 by Positive regulation of striated muscle cell apoptotic process activity — OVARY

Explore this box plot interactively →