Positive regulation of muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COG3, PRKCD, and FLT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle cell apoptotic process activity versus COG3 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COG3 →	-0.252	-0.043	<.001	<.001	3	6
CCRCC	PRKCD →	-0.312	-0.036	<.001	.008	3	6
COAD	FLT1 →	+0.584	+0.041	.005	.007	2	6
BRCA	SEC23B →	-0.229	-0.034	.003	.008	3	5
BRCA	PM20D2 →	+0.658	+0.037	<.001	<.001	3	5
BRCA	COG4_S10 →	-0.491	-0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010661 vs COG3 — BRCA

Explore this scatter interactively →