Positive regulation of muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTNL2, LINC01507, and CENATAC-DT, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle cell apoptotic process activity versus BTNL2 in HNSC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BTNL2 →	+0.206	+0.165	.003	.003	3	3
HNSC	LINC01507 →	+0.426	+0.153	.002	.001	3	3
HNSC	CENATAC-DT →	+0.491	+0.152	.006	.007	3	3
OV	LOXL1-AS1 →	-0.459	-0.172	.009	.001	3	3
PDAC	CYP11B1 →	+0.056	+0.106	.004	.005	3	3
GBM	IRF2-DT →	+0.320	+0.143	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010661 vs BTNL2 — HNSC

Explore this scatter interactively →