Positive regulation of muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC9, CWC15, and SOCS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HDAC9 grouped by Positive regulation of muscle cell apoptotic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HDAC9 →	+2.206	+1.408	.002	.003	3	4
LUNG_NSCLC_LUAD	CWC15 →	+0.613	+0.799	<.001	.001	3	4
LUNG_NSCLC_LUAD	SOCS1 →	+0.789	+0.909	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GATA6 →	+0.989	+1.027	.002	.001	3	4
BLOOD_Leukemia	VEGFB →	+1.509	+1.104	.004	.009	3	4
SOFT_TISSUE	FCHO1 →	-3.178	-1.107	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HDAC9 by Positive regulation of muscle cell apoptotic process activity — SOFT_TISSUE

Explore this box plot interactively →