Positive regulation of muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUDS3, RIC8B, and NRN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUDS3 grouped by Positive regulation of muscle cell apoptotic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SUDS3 →	-0.279	-0.330	.008	<.001	3	5
CNS	RIC8B →	-0.345	-0.353	.001	.005	3	4
OVARY	NRN1 →	+0.094	+0.220	.007	.008	3	4
UPPER_AERODIGESTIVE_TRACT	ARHGAP18 →	+0.144	+0.250	.003	.007	3	4
UPPER_AERODIGESTIVE_TRACT	SOX2 →	-0.139	-0.250	.002	.007	3	4
LUNG_NSCLC_LUSC	HNRNPCL1 →	+0.378	+0.330	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUDS3 by Positive regulation of muscle cell apoptotic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →