Positive regulation of muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIFC3, RAB31, and MED15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle cell apoptotic process activity versus KIFC3 in LUNG_NSCLC_LUSC (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KIFC3 →	+4.390	+0.396	<.001	<.001	3	4
LUNG_NSCLC_LUSC	RAB31 →	+3.090	+0.303	.007	.009	2	5
LUNG_NSCLC_LUSC	MED15 →	+1.003	+0.382	.004	<.001	3	4
LIVER	CAVIN1 →	+2.235	+0.414	.004	.009	3	4
STOMACH	ARMH1 →	+0.940	+0.241	.008	.001	3	4
LARGE_INTESTINE	CBX6 →	+2.103	+0.213	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010661 vs KIFC3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →