Striated muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Striated muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ORAI3, MTCYBP43, and PLOD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle cell apoptotic process activity versus ORAI3 in HNSC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ORAI3 →	+0.414	+0.133	.004	.006	3	4
LSCC	MTCYBP43 →	+0.697	+0.144	<.001	.006	3	3
LSCC	PLOD1 →	+0.511	+0.139	.001	.008	3	3
HNSC	SUN2 →	+0.556	+0.139	.003	<.001	3	3
HNSC	MRC2 →	+0.948	+0.195	<.001	.001	3	3
HNSC	TFEB →	+0.566	+0.189	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010658 vs ORAI3 — HNSC

Explore this scatter interactively →