Striated muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Striated muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3G, CANX, and SEMA3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF3G grouped by Striated muscle cell apoptotic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EIF3G →	-0.400	-0.650	.002	.007	3	3
URINARY_TRACT	CANX →	+0.640	+1.751	.006	<.001	3	3
BREAST	SEMA3B →	+1.827	+0.890	.001	.006	2	4
KIDNEY	GFUS →	-0.738	-0.624	<.001	.009	3	2
KIDNEY	CLPP →	-0.442	-0.632	.002	.008	3	2
KIDNEY	RPL8 →	-0.638	-0.929	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF3G by Striated muscle cell apoptotic process activity — KIDNEY

Explore this box plot interactively →