Muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Muscle cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C2, KRT17_S13, and CNRIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell apoptotic process activity versus AKR1C2 in OV (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AKR1C2 →	+1.606	+0.040	<.001	<.001	3	5
LSCC	KRT17_S13 →	+1.617	+0.031	.004	.005	3	5
OV	CNRIP1 →	+0.724	+0.040	<.001	<.001	3	5
UCEC	COG2 →	-0.207	-0.047	.001	<.001	3	5
HNSC	LIMA1_S609 →	-0.444	-0.031	<.001	.001	3	5
PDAC	COG7 →	-0.179	-0.035	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010657 vs AKR1C2 — OV

Explore this scatter interactively →